ESR1 as a recurrence-related gene in intrahepatic cholangiocarcinoma: a weighted gene coexpression network analysis
نویسندگان
چکیده
منابع مشابه
Intrahepatic cholangiocarcinoma and encephalomalacia in a budgerigar (Melopsittacus undulatus)
Encephalomalacia is softening or loss of brain tissue following cerebral infarction; cerebral ischemia infection, craniocerebral trauma or other injuries. Cholangiocarcinomas are malignant neoplasms of biliary epithelium, which usually arise from the intrahepatic ducts. A budgerigar was presented with a history of ataxia, decreased activity, neck weakness and weight loss. Supportive care was at...
متن کاملGeometric Interpretation of Gene Coexpression Network Analysis
THE MERGING OF NETWORK THEORY AND MICROARRAY DATA ANALYSIS TECHNIQUES HAS SPAWNED A NEW FIELD: gene coexpression network analysis. While network methods are increasingly used in biology, the network vocabulary of computational biologists tends to be far more limited than that of, say, social network theorists. Here we review and propose several potentially useful network concepts. We take advan...
متن کاملMultiplexed gene expression profiling identifies the FGFR4 pathway as a novel biomarker in intrahepatic cholangiocarcinoma
BACKGROUND The fibroblast growth factor receptor 4 (FGFR4) pathway is an essential regulatory component of bile acid synthesis, and its relationship with hepatocellular carcinoma (HCC) has been reported. We investigated the gene expression and clinical significance of FGFR4 and related pathways in intrahepatic cholangiocarcinoma (iCCA). RESULTS The median age was 56 years (range 30-78) and 34...
متن کاملRecurrence after operative management of intrahepatic cholangiocarcinoma.
INTRODUCTION Data on recurrence after operation for intrahepatic cholangiocarcinoma (ICC) are limited. We sought to investigate rates and patterns of recurrence in patients after operative intervention for ICC. METHODS We identified 301 patients who underwent operation for ICC between 1990 and 2011 from an international, multi-institutional database. Clinicopathologic data, recurrence pattern...
متن کاملEYA4 gene functions as a prognostic marker and inhibits the growth of intrahepatic cholangiocarcinoma
BACKGROUND The molecular prognostic markers and carcinogenesis of intrahepatic cholangiocarcinoma (ICC) have not been well documented. The purpose of this study was to investigate the prognostic value of the eyes absent homolog 4 (EYA4) gene in ICC and its biological effects on ICC growth in vitro and in vivo. METHODS One hundred twelve patients with ICC who underwent hepatectomy were enrolle...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Cell International
سال: 2021
ISSN: 1475-2867
DOI: 10.1186/s12935-021-01929-5