ERRATUM: Transmembrane adaptor proteins: organizers of immunoreceptor signalling
نویسندگان
چکیده
منابع مشابه
Transmembrane adaptor proteins in membrane microdomains: important regulators of immunoreceptor signaling.
Membrane microdomains enriched in glycosphingolipids, cholesterol, glycosylphosphatidylinositol-anchored proteins and Src-family kinases (lipid rafts, GEMs) appear to play many important roles, especially in immunoreceptor signaling. Most transmembrane proteins are excluded from these specialized areas of membranes, notable exceptions being several palmitoylated proteins such as the T cell core...
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The plasma membrane contains diverse and specialized membrane domains, which include tetraspanin-enriched domains (TEMs) and transmembrane adaptor protein (TRAP)-enriched domains. Recent biophysical, microscopic, and functional studies indicated that TEMs and TRAP-enriched domains are involved in compartmentalization of physicochemical events of such important processes as immunoreceptor signal...
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To investigate structural features critical for signal initiation by Ag-stimulated immunoreceptors, we constructed a series of single-chain chimeric receptors that incorporate extracellular human Fc epsilonRIalpha for IgE binding, a variable transmembrane (TM) segment, and the ITAM-containing cytoplasmic tail of the TCR zeta-chain. We find that functional responses mediated by these receptors a...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2004
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri1455