Erratum: Id family of helix-loop-helix proteins in cancer

ID helix-loop-helix proteins

The helix-loop-helix (HLH) family of transcription factors comprises >200 members, which have been identified in organisms from yeast to man (reviewed in Littlewood and Evan, 1995; Massari and Murre, 2000). In metazoa, HLH proteins function in the coordinate regulation of gene expression, orchestrating cell cycle control, cell lineage commitment and cell differentiation. An essential role has b...

. binding by one class of helix - loop - helix Id proteins Id 1 and Id 2 selectively inhibit DNA

Id helix-loop-helix proteins are differentially expressed in gestational trophoblastic disease.

AIMS To assess the expression of Id proteins in trophoblastic tissues and to correlate this with clinical parameters, proliferative and apoptotic indices as well as to related oncogene expression. METHODS AND RESULTS Immunohistochemistry for Id1, Id2, Id3 and Id4 was performed on 83 trophoblastic tissues including 17 normal first-trimester placentas, seven term placentas, 47 hydatidiform mole...

Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation.

Tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE) induces osteoclast formation from monocyte/macrophage lineage cells via various transcription factors, including the Mi transcription factor (Mitf). Here, we show that inhibitors of differentiation/DNA binding (Ids), helix-loop-helix (HLH) transcription factors, negatively regulate TRANCE-induced osteoclast differentiation...

Early growth response gene2 negatively modulates osteoclast differentiation by up-regulating Id helix-loop-helix proteins

INTRODUCTION Osteoclasts are derived from hematopoietic precursors in the presence of macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL). Binding of RANKL to its receptor RANK activates NF-κB, c-fos, and NFATc1, all of which are essential for osteoclastogenesis. The inhibitor of differentiation/DNA binding (Id), helix-loop-helix (HLH) proteins act as dom...