Epigenomic Regulation of SATB2 Links Maternal Obesity to Impaired Osteoblast Differentiation (P11-034-19)

Regulation of Osteoblast Differentiation by Micrornas

SATB2 Is a Multifunctional Determinant of Craniofacial Patterning and Osteoblast Differentiation

Vertebrate skeletogenesis involves two processes, skeletal patterning and osteoblast differentiation. Here, we show that Satb2, encoding a nuclear matrix protein, is expressed in branchial arches and in cells of the osteoblast lineage. Satb2-/- mice exhibit both craniofacial abnormalities that resemble those observed in humans carrying a translocation in SATB2 and defects in osteoblast differen...

Transcriptional regulation of osteoblast differentiation during development.

The osteoblast is the bone-forming cell. The molecular basis of osteoblast-specific gene expression and differentiation begin to be understood. Following the characterization of OSE2, an osteoblast-specific cis-acting element present in the Osteocalcin promoter Osf2/Cbfa1, the protein that binds to OSE2, was identified. Osf2/Cbfa1 is a member of the runt family of transcription factors. Its exp...

Genomic and epigenomic regulation of adipose tissue inflammation in obesity.

Chronic inflammation of adipose tissue is viewed as a hallmark of obesity and contributes to the development of type 2 diabetes and cardiovascular disease. According to current models, nutrient excess causes metabolic and structural changes in adipocytes, which initiate transcriptional programs leading to the expression of inflammatory molecules and the subsequent recruitment of immune cells. R...

MicroRNAs: Synthesis, Gene Regulation and Osteoblast Differentiation.

The central dogma of transfer of genetic information from DNA to protein via mRNA is now challenged by small fragment of non coding RNAs typically 19-25 nucleotides in length namely microRNAs (miRNAs). miRNAs regulate expression of the protein coding genes by interfering in their mRNAs and, thus, act as key regulators of diverge cellular activities. Osteoblast differentiation, a key step in ske...