Enzyme-mediated hydrolytic activation of prodrugs
نویسندگان
چکیده
منابع مشابه
Enzyme-catalyzed activation of anticancer prodrugs.
The rationale fo the development of prodrugs relies upon delivery of higher concentrations of a drug to target cells compared to administration of the drug itself. In the last decades, numerous prodrugs that are enzymatically activated into anti-cancer agents have been developed. This review describes the most important enzymes involved in prodrug activation notably with respect to tissue distr...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica Sinica B
سال: 2011
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2011.08.001