Entecavir as a P2X7R antagonist ameliorates platelet activation and thrombus formation
نویسندگان
چکیده
منابع مشابه
Platelet Activation and Thrombus Formation at the Vessel Wall
Antiplatelet and anticoagulant drugs, used alone or in combination, are a cornerstone of clinical treatment for human diseases associated with increased athero/thrombotic risks, such as heart attack and stroke, and in preventing thrombosis during surgery or other medical procedures involving vascular disruption or perturbed blood flow. The confounding issue is that rapid platelet activation and...
متن کاملEMILIN2 Regulates Platelet Activation, Thrombus Formation, and Clot Retraction
Thrombosis, like other cardiovascular diseases, has a strong genetic component, with largely unknown determinants. EMILIN2, Elastin Microfibril Interface Located Protein2, was identified as a candidate gene for thrombosis in mouse and human quantitative trait loci studies. EMILIN2 is expressed during cardiovascular development, on cardiac stem cells, and in heart tissue in animal models of hear...
متن کاملChlorogenic Acid Inhibits Human Platelet Activation and Thrombus Formation
BACKGROUND Chlorogenic acid is a potent phenolic antioxidant. However, its effect on platelet aggregation, a critical factor in arterial thrombosis, remains unclear. Consequently, chlorogenic acid-action mechanisms in preventing platelet activation and thrombus formation were examined. METHODS AND RESULTS Chlorogenic acid in a dose-dependent manner (0.1 to 1 mmol/L) inhibited platelet secreti...
متن کاملPlatelet Thrombus Formation
severe homozygous von Willebrand factor (vWF)-deficient pigs (vWF<3%) (n=6), and heterozygous vWF-deficient pigs (vWF=24%) (n=2). Thrombus formation was measured by autologous "'In-platelet labeling and by ultrastructural morphology. Heparinized and native blood from these pigs was perfused over the substrate for 3 and 5 minutes at local shear rates from 212 to 3,380/sec. On collagen type I exp...
متن کاملGlaucocalyxin A Inhibits Platelet Activation and Thrombus Formation Preferentially via GPVI Signaling Pathway
Platelets play a pivotal role in atherothrombosis and the antiplatelet agents have been proved to be useful in preventing onset of acute clinical events including myocardial infarction and stroke. Increasing number of natural compounds has been identified to be potential antiplatelet agents. Here we report the antiplatelet effect of glaucocalyxin A (GLA), an ent-diterpenoid that we isolated and...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2020
ISSN: 1347-8613
DOI: 10.1016/j.jphs.2020.07.002