Engineered bone cement trigger bone defect regeneration

Bone defects, which can be caused by factors such as trauma, tumor, or osteomyelitis, are clinically common. They lessen the weight a bone is able to bear and cause severe pain patient. Although transplantation gold standard for treating it not suitable all patients due its poor availability, risk of spreading disease, possibility requiring secondary surgery. cement filler defects fill any shape defect, quickly solidify when injected, providing mechanical strength sufficient supporting normal physiological activities bone. However, traditional lacks ability induce regeneration. Recently, various methods enhancing regeneration have been developed, adding morphogenetic proteins, mesenchymal stem cells, inorganic substances cement. These only ensure original biological properties cement, but also improve in terms The aim this review overview process regeneration, introduce improved formulations designed promote discuss clinical application possibilities future improvement.