Encoding of Contextual Fear Memory Requires De Novo Proteins in the Prelimbic Cortex
نویسندگان
چکیده
منابع مشابه
Activity in prelimbic cortex subserves fear memory reconsolidation over time.
The prelimbic cortex has been implicated in the consolidation of previously learned fear. Herein, we report that temporarily inactivating this medial prefrontal cortex subregion with the GABAA agonist muscimol (4.0 nmol in 0.2 μL per hemisphere) was able to equally disrupt 1-, 7-, and 21-d-old contextual fear memories after their brief retrieval in rats. In all cases, this effect was prevented ...
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Rats can learn to forage among olfactory cues to associate one with reward in only 3 massed trials. The learning is achieved in less than 10 min and results in a memory trace lasting at least 1wk week. To study the neuro-anatomical circuits involved in the memory formation we used immunoreactivity to the immediate early gene c-fos as a marker for neuronal activity induced by the learning. The p...
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Several experiments have demonstrated an intimate relationship between hippocampal theta rhythm (4-12 Hz) and memory. Lesioning the medial septum or fimbria-fornix, a fiber track connecting the hippocampus and the medial septum, abolishes the theta rhythm and results in a severe impairment in declarative memory. To assess whether there is a causal relationship between hippocampal theta and memo...
متن کاملEarly and late consolidation and reconsolidation of memory in the prelimbic cortex
Rats can learn to forage among olfactory cues to associate one with reward in only 3 massed trials. The learning is achieved in less than 10 min and results in a memory trace lasting at least 1wk week. To study the neuro-anatomical circuits involved in the memory formation we used immunoreactivity to the immediate early gene c-fos as a marker for neuronal activity induced by the learning. The p...
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ژورنال
عنوان ژورنال: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
سال: 2017
ISSN: 2451-9022
DOI: 10.1016/j.bpsc.2016.10.002