Effects of zileuton and montelukast in mouse experimental spinal cord injury

Systemic Effects of Experimental Spinal Cord Injury on Bone Healing in Rabbit

Bone loss after spinal cord injury leads to increased fragility of bone and subsequent risk for low-trauma fractures in the sublesional parts of the body. Although in such injuries upper limbs are normally innervated, bone loss may occur in the upper extremities. The present study was designed to determine the systemic effects of spinal cord injury on the fracture healing of upper limbs in rabb...

Microglial Activation in Rat Experimental Spinal Cord Injury Model

Background: The present study was designed to evaluate the secondary microglial activation processes after spinal cord injury (SCI). Methods: A quantitative histological study was performed to determine ED-1 positive cells, glial cell density, and cavitation size in untreated SCI rats at days 1, 2, and 4, and weeks 1, 2, 3, and 4. Results: The results of glial cell quantification along the 4900...

Effect of Aspirin on Spinal Cord Injury: An Experimental Study

Aspirin is an anti-inflammatory drug, peroxyl radical scavenger, and antioxidant agent that inhibits phospholipases, nitric oxide synthetases, and cyclooxygenase enzymes. The existing literature contains no studies on the effects of various doses of aspirin on spinal cord injury (SCI). Therefore, we sought to investigate the putative effects of aspirin on experimental SCI.The weight-drop injury...

Effect of Montelukast on Spinal Cord Ischemia- Reperfusion Injury.

AIM Paraplegia due to ischemia-reperfusion (I/R) injury of the spinal cord is a devastating complication of thoracoabdominal aortic surgery. Cysteinyl leukotrienes are potent mediators of inflammation that are associated with I/R injury. The present study was designed to investigate the role of montelukast, a selective reversible CysLT1 receptor antagonist, on spinal cord I/R injury in an exper...

Biomechanical Responses to Experimental open Spinal Cord Injury