Effects of amphotericin B on hepatitis B virus

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Effects of amphotericin B on hepatitis B virus.

We investigated the effects of amphotericin B (AmB) on the ultrastructure and biochemistry of hepatitis B virus (HBV) and hepatitis B surface antigen (HBsAg) particles. These effects were compared with those reported for AmB and other polyene antibiotics on other lipid-enveloped viruses and artificial membranes. Treatment of HBV particles with concentrations of AmB ranging from 5 to 250 microgr...

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Abstract       Background and objective: Hepatitis B virus (HBV) is a DNA virus with high tendency toward hepatic tissue. There are currently about 3 million HBV-infected people and 350 to 400 million chronic carriers of this virus in the world. X protein plays a role in the over-expression of oncogenes, carcinogenicity of liver cells and overlaps with the basal co...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1981

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.20.6.826