Effect of oral sodium cromoglycate and ketotifen in fish-induced bronchial asthma.
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چکیده
منابع مشابه
Effect of oral sodium cromoglycate and ketotifen in fish-induced bronchial asthma.
The effects of sodium cromoglycate and ketotifen were studied in a group of 20 patients in whom fish repeatedly provoked an attack of wheezing and dyspnoea within one hour of its being eaten. Fish ingestion resulted in a fall in forced expiratory volume in one second (FEV1) of at least 15%. All patients had a weal greater than 4 mm in response to fish antigen in the skinprick test and most had ...
متن کاملBronchial reactivity to histamine before and after sodium cromoglycate in bronchial asthma.
Out of 19 patients with extrinsic bronchial asthma challenged with 123 mug histamine acid phosphate by intravenous infusion only 13 responded with a fall in FEV1 of over 10% (mean 16%). Seventeen of these patients were given histamine 2 mg/ml by aerosol, and all responded with a mean decrease in FEV1 of 37.8%. When challenged with allergen extract by aerosol the mean decrease in FEV1 was 37.5%....
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Ketotifen (Zaditen), a benzocycloheptathiophene derivative, is a new oral agent for treating asthma, with action similar in some respects to that of sodium cromoglycate. It is well established that sodium cromoglycate protects against antigen challenge by inhibiting the release of chemical mediators from mast cells. It also inhibits exerciseinduced bronchoconstriction and has bronchodilator pro...
متن کاملSodium cromoglycate in nocturnal asthma.
To investigate whether mast cell degranulation was important in producing nocturnal asthma, the effect of a single high dose of nebulised sodium cromoglycate on overnight bronchoconstriction, oxygen saturation, and breathing patterns in eight patients with nocturnal wheeze was examined. The study took the form of a double blind placebo controlled crossover comparison. Treatment with cromoglycat...
متن کاملSodium cromoglycate in childhood asthma.
The review of placebo controlled trials of sodium cromoglycate (SCG) in childhood asthma by Tasche et al concludes that “there is insuYcient evidence that SCG has a beneficial eVect as maintenance treatment in children with asthma”. We do not believe this conclusion is justified. The principal criteria for assessing the eYcacy of inhaled SCG are the mean diVerences in the eVect on the symptoms ...
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ژورنال
عنوان ژورنال: Thorax
سال: 1983
ISSN: 0040-6376
DOI: 10.1136/thx.38.7.527