Effect of Lysolecithin, Digitonin, and Phospholipase a Upon the Dog’s Gastric Mucosal Barrier

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Effect of lysolecithin on gastric mucosal structure and potential difference.

The effect of lysolecithin (100 mg%) on the guinea-pig gastric mucosa was studied by instilling a solution for 30 minutes, preceded and followed by 100 MN HCl into 10 total gastric pouches. Ten control animals had HCl throughout. Lysolecithin produced a significant change in transmucosal potential difference, macroscopic erosions, and mucosal damage on histology and electron scanning microscopy...

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Effect of gastric secretory inhibitors on the gastric mucosal barrier.

The effects of the synthetic prostaglandin 16, 16 dimethyl-E2 methyl ester (16-diMe-PGE2) and the histamine H2-receptor antagonist metiamide on the gastric mucosal barrier have been studied using the Heidenhain pouch dog model. The 16-diMe-PGE2 caused significant change in the ionic permeability of the mucosa when instilled into the pouch in a concentration of 300 mug/20 ml. Intravenous adminis...

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Gastric mucosal integrity can be influenced both by peripheral and central mechanisms. In the last decades the peripheral mechanisms of gastric mucosal defense have been intensively studied, and many details have been clarified. Some of these results have served as a basis for the development of new strategies, therapeutic targets in the treatment of gastric mucosal lesions. On the other hand, ...

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ژورنال

عنوان ژورنال: Gastroenterology

سال: 1970

ISSN: 0016-5085

DOI: 10.1016/s0016-5085(19)33701-1