Effect of estradiol valerate on endometrial thickness in polycystic ovary syndrome having ovulation induction with letrozole

Background: PCOS is a common endocrine disorder in women of reproductive age. Letrozole an orally active aromatase inhibitor and as effective chlomiphene citrate for induction ovulation. Estrogen important the regeneration growth endometrium prior to ovulation prepare tissue respond progesterone post patients. Aim study was assess effects estradiol valerate on endometrial thickness having with letrozole. Methods: This randomized controlled conducted department endocrinology infertility, BSMMU, Dhaka, 1 year duration. A total 80 diagnosed cases patients subfertility were included this study. Among them 40 received letrozole placebo. Results: On day 8, mean not statistically significant between two groups (p=0.436). triggering, significantly higher intervention group 9.2±1.4 mm than control 8.2±1.4 (p=0.004). Mean changes triggering compared 8 3.2±1.5 2.5±1.6 (p=0.043). Pregnancy rate 13 (38.2%) (22.2%) relative risk 1.72, 95% CI (0.82-3.63%), that (p=0.144). Conclusions: group. The pregnancy achieved letrozole+estradiol combination placebo