Ecological aspects of the multidrug resistance to chemotherapy agents
نویسندگان
چکیده
منابع مشابه
Cancer multidrug resistance (MDR): a major impediment to effective chemotherapy.
Multidrug resistance (MDR) continues to be a major challenge to effective chemotherapeutic interventions against cancer. Various types of cancers have been observed to exhibit this phenomenon, a strategy that involves cellular and non cellular mechanisms employed by cancer cells to survive the cytotoxic actions of various structurally and functionally unrelated drugs. The present article is a b...
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Irreversible growth arrest (also called senescence) has emerged recently as a tumor suppressor mechanism and a key determinant of cancer chemotherapy outcome. Previous work from our laboratory suggested that the cellular ability to undergo or to escape senescence dictates its fate to become drug-sensitive or drug-resistant, respectively. In the present study, we made the hypothesis that longevi...
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Background: Treatment of chronic sinusitis is complicated due to increase of antibiotic-resistant bacteria. The aim of this study was to determine the multidrug resistance (MDR) pattern of the bacteria causing chronic sinusitis in north of Iran. Methods: This cross-sectional study was carried out on patients with chronic sinusitis. Bacterial susceptibility to antimicrobial agents was determi...
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Cancer cell resistance to chemotherapy is still a heavy burden that impairs treatment of cancer patients. Both intrinsic and acquired resistance results from the numerous genetic and epigenetic changes occurring in cancer cells. Most of the hallmarks of cancer cells provide general mechanisms to sustain stresses such as the ones induced by chemotherapeutic drugs. Moreover, specific changes in t...
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chapter i provides an overview of structural linguistics and touches upon the saussurean dichotomies with the final goal of exploring their relevance to the stylistic studies of literature. to provide evidence for the singificance of the study, chapter ii deals with the controversial issue of linguistics and literature, and presents opposing views which, at the same time, have been central to t...
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ژورنال
عنوان ژورنال: Principles of the Ecology
سال: 2012
ISSN: 2304-6465
DOI: 10.15393/j1.art.2012.921