Drug-Associated Acute Lung Injury During Amiodarqne Uptake

Drug-associated acute lung injury: a population-based cohort study.

BACKGROUND A number of drugs have been reported as risk factors for acute lung injury (ALI) and ARDS. However, evidence is largely limited to case reports, and there is a paucity of data on the incidence and outcome of drug-associated ALI (DALI). METHODS Using a population-based retrospective cohort study design, critically ill patients with a diagnosis of ALI were studied. These patients wer...

Acute Lung Injury During Cardiopulmonary

or hypothermic (n=19, 29.2±0.5°C) CPB. The cellular response to the extracorporeal circulation was signif¬ icantly delayed in the hypothermic group with a later onset of neutrophilia and a later increase in plasma elastase levels during bypass. Lung function deterio¬ rated significantly after CPB as assessedby respiratory index, alveolar-arterial oxygen gradient, and intrapulmonary shunt, indep...

Pancreatitis-associated acute lung injury: new insights.

Collagen breakdown during acute lung injury.

Injury to the capillary endothelium and to alveolar epithelial cells of the lung may result in damage to the underlying collagen of the extracellular matrix. To examine this possibility, whole body irradiation, bleomycin injections, and exposure to hyperoxia were used to induce various types of lung damage in mice. The morphology of the lung and the cellular and protein content of bronchoalveol...

Hypoxia signaling during acute lung injury.

Acute lung injury (ALI) is an inflammatory lung disease that manifests itself in patients as acute respiratory distress syndrome and thereby contributes significantly to the morbidity and mortality of patients experiencing critical illness. Even though it may seem counterintuitive, as the lungs are typically well-oxygenated organs, hypoxia signaling pathways have recently been implicated in the...