Double-Hit Lymphoma with t(8;14)(q24;q32) and t(12;14)(q24;q32) Chromosomal Translocations
نویسندگان
چکیده
منابع مشابه
Chromosomal translocations involving BCL6 in MALT lymphoma.
Chromosomal translocations involving BCL6 were detected in 7 out of 392 cases of MALT lymphoma by interphase fluorescence in situ hybridisation with a BCL6 break-apart probe. With the exception of BCL6 protein expression in 2 of the 7 cases, these BCL6 translocation-positive MALT lymphomas were histologically and immunophenotypically identical to classic cases.
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Double hit lymphoma (DHL), commonly defined as an aggressive B cell non-Hodgkin lymphoma (NHL) harboring rearrangement of MYC as well as BCL2 and/or BCL6, has recently been formally categorized as “High grade B-cell lymphoma [HGBL], with rearrangements of MYC and BCL2 and/or BCL6” as per the 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms. Patients with...
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Rivera XI, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-220401 Description A 67-year-old woman with history of severe rheumatoid arthritis and use of multiple biologics including infliximab, tocilizumab and abatacept presented with fever of 39.1°C and severe pancytopenia (white blood cell count (WBC)=1.0×10/L, absolute neutrophil count (ANC)=0.55×10/L, haemoglobin=8.7 g/ dL, platelets=46×10/L...
متن کاملHow I treat double-hit lymphoma.
The 2016 revision of the World Health Organization (WHO) classification for lymphoma has included a new category of lymphoma, separate from diffuse large B-cell lymphoma, termed high-grade B-cell lymphoma with translocations involving myc and bcl-2 or bcl-6. These lymphomas, which occur in <10% of cases of diffuse large B-cell lymphoma, have been referred to as double-hit lymphomas (or triple-h...
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Tolosa-Hunt syndrome (THS) is a painful condition characterized by hemicranial pain, retroorbital pain, loss of vision, oculomotor nerve paralysis, and sensory loss in distribution of ophthalmic and maxillary division of trigeminal nerve. Lymphomas rarely involve cavernous sinus and simulate Tolosa-Hunt syndrome. Here we present a first case of double-hit B cell lymphoma (DHL) relapsing and mas...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 2011
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.50.5815