Do mantle cell lymphomas have an ‘Achilles heel’?

Does Plasmodium falciparum have an Achilles' heel?

BACKGROUND Plasmodium falciparum is the parasite that causes the most severe form of malaria responsible for nearly a million deaths a year. Currently, science has been established about its cellular structures, its metabolic processes, and even the molecular structures of its intrinsic membrane proteins responsible for transporting water, nutrient, and waste molecules across the parasite plasm...

Tumor cell metabolism: cancer's Achilles' heel.

The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic metabolism, either as a consequence or as a cause. As an example, the resistance of cancer mitochondria against apoptosis-associated permeabilization and the altered contribution of these organelles to metabolism are closely related. Similarly, the constitutive activation of signaling cascades that stimulate...

An Achilles' Heel of Term-Resolution

Term-resolution provides an elegant mechanism to prove that a quantified Boolean formula (QBF) is true. It is a dual to Q-resolution (also referred to as clause-resolution) and is practically highly important as it enables certifying answers of DPLL-based QBF solvers. While term-resolution and Q-resolution are very similar, they’re not completely symmetric. In particular, Q-resolution operates ...

Cancer's new Achilles' heel?

Claims to the discovery of cancers Achilles’ heel are multiple, even clichéd. Analogies to this Greek myth usually refer to the fall of the undefeatable, yet the novelty behind the legend is that a seemingly immortal foe could be toppled by something so innocuous as his heel. This may be the case for cancer and a non-coding mitochondrial RNA that as yet has no known physiological function or me...

Ideology: Criminology's Achilles' Heel?