Diurnal variation of neutropenia during clozapine treatment
نویسندگان
چکیده
منابع مشابه
Rechallenging with clozapine following neutropenia: treatment options for refractory schizophrenia.
Clozapine, a second-generation antipsychotic, is the treatment of choice in refractory schizophrenia because of its proven efficacy over typical antipsychotics as well as other atypical antipsychotics (1). However, a major drawback to clozapine therapy is the increased risk of neutropenia and agranulocytosis (2). In patients who develop either of these serious side effects, clozapine is immedia...
متن کاملRechallenge with clozapine following leucopenia or neutropenia during previous therapy.
BACKGROUND Further treatment with clozapine is contraindicated in any patient who has previously experienced leucopenia or neutropenia during clozapine therapy. AIMS To investigate the results of such a rechallenge in 53 patients. METHOD An analysis was made of the demographic, haematological and outcome data of patients in the UK and Ireland who were rechallenged with clozapine following l...
متن کاملCerebroventricular clozapine would be a viable treatment modality for clozapine-dependent schizophrenia patients with neutropenia.
The atypical antipsychotic clozapine is very effective for treatment of schizophrenia, but it causes agranulocytosis requiring drug cessation in up to 2% of cases. There has been some success rechallenging with clozapine at a later date or giving granulocyte colony stimulating factor or lithium while continuing clozapine. However, there are still some patients for whom these strategies do not w...
متن کاملClozapine-Induced Febrile Neutropenia and Cellulitis
Clozapine is one of the atypical antipsychotics and is frequently prescribed to patients with treatment-resistant schizophrenia. Agranulocytosis is a major side effect that may lead to death, which limits its use. This is a case report of a patient that developed febrile neutropenia and cellulitis after treatment with clozapine for 20 weeks.
متن کاملClozapine, agranulocytosis, and benign ethnic neutropenia.
C lozapine is an atypical antipsychotic that is effective in treatment resistant schizophrenia. The National Institute for Health and Clinical Excellence (NICE) guidelines for schizophrenia specify that ‘‘in individuals with evidence of treatment resistant schizophrenia, clozapine should be introduced at the earliest opportunity’’. A severe adverse effect of clozapine that limits its more wides...
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ژورنال
عنوان ژورنال: The International Journal of Neuropsychopharmacology
سال: 2005
ISSN: 1461-1457,1469-5111
DOI: 10.1017/s1461145705006061