Distribution of sigma factors delineates segregation of virulent and avirulent Mycobacterium
نویسندگان
چکیده
منابع مشابه
Comparative Proteomic Analyses of Avirulent, Virulent, and Clinical Strains of Mycobacterium tuberculosis Identify Strain-specific Patterns*
Mycobacterium tuberculosis is an adaptable intracellular pathogen, existing in both dormant as well as active disease-causing states. Here, we report systematic proteomic analyses of four strains, H37Ra, H37Rv, and clinical isolates BND and JAL, to determine the differences in protein expression patterns that contribute to their virulence and drug resistance. Resolution of lysates of the four s...
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Mycobacterium tuberculosis H37Rv causes progressive disease in animals, whereas the H37Ra strain does not. The relevance of this difference in virulence to human infection is uncertain because these strains have been shown to have similar growth rates in human macrophages. To evaluate the intracellular growth of M. tuberculosis strains in macrophages under conditions similar to those encountere...
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Introduction: Bacteria have at least one sigma factor (σ-factor) that transcribes the genes required for cell viability. Usually, transcription of σ-factors occurs and changes in response to a variety of environmental stresses. Expression of σ-factors is one of the strategies which is used in response to different stress conditions. This study was aimed to evaluate the effects...
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The bactericidal activity of the aminoglycoside gentamicin has been demonstrated against a broad spectrum of bacteria (Jackson and Finland, 1969). This spectrum included Neisseria gonorrhoeae (Waitz and Weinstein, 1969); however, before gentamicin is used for the treatment of gonorrhoea, its effect on Treponema pallidum should be investigated to determine whether it can delay or mask the develo...
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ژورنال
عنوان ژورنال: Archives of Microbiology
سال: 2021
ISSN: 0302-8933,1432-072X
DOI: 10.1007/s00203-020-02172-8