Dissolution profiles of fenbendazole from binary solid dispersions: a mathematical approach

Aim: Understanding a drug dissolution process from solid dispersions (SD) to develop formulations with predictable in vivo performance. Materials & methods: Dissolution data of fenbendazole released the SDs and control physical mixtures were analyzed using Lumped mathematical model estimate parameters pharmaceutical relevance. Results: The fit obtained by showed that all have unique profile an error ±4.1% initial release rate 500-times higher than pure drug, without incidence drug/polymer ratio or polymer type. Conclusion: helped understand main factor influencing was type formulation (SD mixture), regardless amount used.