Disentangling Microbial Mediators of Malnutrition: Modeling Environmental Enteric Dysfunction
نویسندگان
چکیده
منابع مشابه
Environmental enteric dysfunction: an overview.
BACKGROUND Environmental enteric dysfunction (EED) refers to an incompletely defined syndrome of inflammation, reduced absorptive capacity, and reduced barrier function in the small intestine. It is widespread among children and adults in low- and middle-income countries. Understanding of EED and its possible consequences for health is currently limited. OBJECTIVE A narrative review of the cu...
متن کاملSecondary Carnitine Deficiency in Environmental Enteric Dysfunction
Article history: Received 14 February 2017 Accepted 14 February 2017 Available online 16 February 2017 score so as to have a composite index for EED (Kosek et al., 2013). In this study, the plasma from the children was analyzed by LC-MS using a discovery platform and 677 metabolites were definitively identified with relative quantitation. Using a false discovery rate approach, 77 of these metab...
متن کاملAn Exposome Perspective on Environmental Enteric Dysfunction
BACKGROUND Environmental exposures to chemicals have been shown to influence gastrointestinal function, yet little is known regarding whether chemical mixtures may be involved in the development of a subclinical enteric dysfunction found in infants and children born into poor hygiene and sanitation. Advances in gastrointestinal and immunotoxicology fields merit inclusion in complex discussions ...
متن کاملEnvironmental Enteric Dysfunction: Advancing Current Knowledge
when available) was reviewed by two analysts to determine inclusion status for the EED Library. Dual review reduces bias and inaccuracies in the systematic review process. The principal investigators (DMD and PIT) initially piloted the Library inclusion process, until 100% concordance was achieved upon independent review of 1,300 consecutive references. A series of training sessions to convey t...
متن کاملEnvironmental enteric dysfunction pathways and child stunting: A systematic review
BACKGROUND Environmental enteric dysfunction (EED) is commonly defined as an acquired subclinical disorder of the small intestine, characterized by villous atrophy and crypt hyperplasia. EED has been proposed to underlie stunted growth among children in developing countries. A collection of biomarkers, organized into distinct domains, has been used to measure different aspects of EED. Here, we ...
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ژورنال
عنوان ژورنال: Cellular and Molecular Gastroenterology and Hepatology
سال: 2019
ISSN: 2352-345X
DOI: 10.1016/j.jcmgh.2018.12.006