Diastereoselective C−H Bond Amination for Disubstituted Pyrrolidines
نویسندگان
چکیده
منابع مشابه
syn-1,2-Amino alcohols via diastereoselective allylic C-H amination.
syn-1,2-Amino alcohols are prevalent motifs in a diverse range of important small molecules such as natural products, pharmaceuticals, and asymmetric catalysts. The majority of methods for selectively constructing 1,2-amino alcohols rely on functional group interconversions or C-C bond-forming reactions using preoxidized materials.1 Selective methods for directly installing nitrogen functionali...
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The asymmetric synthesis of substituted pyrrolidines has been accomplished using a novel organocatalytic cyclization reaction promoted by a Cinchona alkaloid based primary amine. The reaction proceeds smoothly yielding pyrrolidine-2,2-dicarboxylates after in situ diastereoselective reduction with high levels of enantioselection. Furthermore, these adducts could be easily transformed into N-prot...
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A highly diastereoselective Ugi reaction involving a chiral cyclic imine, two enantiomerically pure isocyanides and various carboxylic acids was employed for the synthesis of polyfunctionalized pyrrolidines. Both chiral substrates have been efficiently prepared by chemoenzymatic methodologies from readily available achiral substrates. This highly convergent approach can find an application in t...
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For the first time, arylmethylidene cyclohexanones that are non-symmetrical due to the presence of peripheral substituents were studied in 1,3-dipolar cycloaddition reactions. It is shown that the interaction with the azomethine ylide generated from sarcosine proceeds regio- and diastereoselectively, with the participation of two non-equivalent parts of the dipolarophile. Also for the first tim...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2017
ISSN: 1433-7851,1521-3773
DOI: 10.1002/anie.201708519