Diagnostic microfluidic immunoassays — go with the flow

Microfluidic Immunoassays

Immunoassays in microfluidic systems.

Immunoassays have greatly benefited from miniaturization in microfluidic systems. This review, which summarizes developments in microfluidics-based immunoassays since 2000, includes four sections, focusing on the configurations of immunoassays that have been implemented in microfluidics, the main fluid handling modalities that have been used for microfluidic immunoassays, multiplexed immunoassa...

Go with the flow.

Physiologists have long recognized that blood vessels vasodilate in response to an increase of flow through their lumen.1 This flow-mediated vasodilation is not due to changes in luminal pressure, but rather to the tractive force of fluid flow, or shear stress.2–4 The endothelium senses shear stress by means of a mechanotransducer apparatus that is not fully defined but that may involve cytoske...

Particles go with the flow

When dropping small particles into a turbulent fluid, we know from daily experience that the particles will be swept up in the swirling eddies and vortices of the fluid motion. But how will the particles be arranged in the flow, and does the addition of these particles smooth out the flow or make it more turbulent? These questions not only have industrial and technological implications, but are...

Thrombolysis: go with the flow.