Developing T cells form an immunological synapse for passage through the ?-selection checkpoint

The Immunological Synapse T. Klemmensen: The Immunological Synapse

The induction of a proper adaptive immune response is dependent on the correct transfer of information between antigen-presenting cells (APCs) and antigen-specific T cells. Defects in information transfer may result in the development of diseases, e.g. immunodeficiencies and autoimmunity. A distinct 3-dimensional supramolecular structure at the T cell/APC interface has been suggested to be invo...

Immunological synapse arrays: patterned protein surfaces that modulate immunological synapse structure formation in T cells.

T cells are activated by recognition of foreign peptides displayed on the surface of antigen presenting cells (APCs), an event that triggers assembly of a complex microscale structure at the T cell-APC interface known as the immunological synapse (IS). It remains unresolved whether the unique physical structure of the synapse itself impacts the functional response of T cells, independent of the...

Immunological Synapse Formation Conjugates with APCs but Are Defective in Orally Tolerized T Cells Can Form

Formation in Adaptively Tolerant T Cells Impairment of Immunological Synapse

Through Immunological Synapse Acquisition of Viral Receptor by NK Cells