DENERVATION SUPERSENSITIVITY: THE RESPONSE TO DEPOLARIZING MUSCLE RELAXANTS

Denervation supersensitivity: the response to depolarizing muscle relaxants.

The chemical theory of neuromuscular transmission (Dale, Feldberg and Vogt, 1936) is now almost universally accepted, and implicates acetylcholine as the neuromuscular transmitter. Depolarizing muscle relaxants act, at least initially, in a manner similar to acetylcholine and are believed to produce their effects by prolonged depolarization, but in certain situations these agents, instead of pr...

Renal denervation supersensitivity revisited.

To determine whether the chronically denervated kidney is supersensitive to either physiological or pathophysiological plasma levels of norepinephrine (NE), studies were conducted in conscious dogs subjected to unilateral renal denervation and surgical division of the urinary bladder into hemibladders to allow separate 24-h urine collection from denervated and innervated kidneys. Plasma NE conc...

Changes in resistance to mouth opening induced by depolarizing and non-depolarizing neuromuscular relaxants.

Mouth opening was measured in 43 children anaesthetized with isoflurane and paralysed with vecuronium or suxamethonium. Measurements of mouth opening were made for up to 10 min after loss of the adductor pollicis twitch and cessation of muscle fasciculations. In 22 patients receiving suxamethonium, a significant (P less than 0.001) reduction in mean mouth opening occurred in the 60 s after loss...

Does cerebral vasospasm result from denervation supersensitivity?

This study examined the role of denervation supersensitivity in the development of cerebral vasospasm. Adrenergic denervation of cat basilar artery was accomplished by resection of the superior cervical ganglia or by injection of 6-hydroxydopamine into the cisterna magna. In vivo dose-response characteristics were determined for normal and for denervated arteries, and no significant differences...

Title The Supersensitivity of Vascular Smooth Muscle Following Surgical Renal Denervation in the Dog