Decoupling Internalization, Acidification and Phagosomal-Endosomal/lysosomal Fusion during Phagocytosis of InlA Coated Beads in Epithelial Cells

Decoupling Internalization, Acidification and Phagosomal-Endosomal/lysosomal Fusion during Phagocytosis of InlA Coated Beads in Epithelial Cells

BACKGROUND Phagocytosis has been extensively examined in 'professional' phagocytic cells using pH sensitive dyes. However, in many of the previous studies, a separation between the end of internalization, beginning of acidification and completion of phagosomal-endosomal/lysosomal fusion was not clearly established. In addition, very little work has been done to systematically examine phagosomal...

Phagosomal acidification: measurement, manipulation and functional consequences.

Phagocytosis holds a central position in the development of a successful innate immune response and in the initiation of the corresponding adaptive response. The destruction of invading pathogens and the presentation of their antigens to lymphoid cells require acidification of the phagosomal lumen. The present review discusses the mechanism of phagosome acidification, with particular reference ...

Cftr-independent Phagosomal Acidification in Macrophages

It was reported recently that the cystic fibrosis conductance regulator protein (CFTR) is required for acidification of phagosomes in alveolar macrophages (Di et al. Nature Cell Biol. 8:933–944, 2006). Here we determined whether the CFTR chloride channel is a generalized pathway for chloride entry into phagosomes of macrophages and whether mutations in CFTR could contribute to alveolar macropha...

Phagocytosis and Phagosome Acidification

effectiveness of hedstroum files and rotary k3 instruments in removal of obturation materials during retreatment in curved canals

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