Dacomitinib-induced diarrhea: Targeting chloride secretion with crofelemer
نویسندگان
چکیده
منابع مشابه
Crofelemer for the treatment of chronic diarrhea in patients living with HIV/AIDS
Diarrhea is a common comorbidity present in patients with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) who are treated with highly active antiretroviral therapy. With a multifactorial etiology, this diarrhea often becomes difficult to manage. In addition, some antiretrovirals are associated with chronic diarrhea, which potentially creates an adherence barrier to a...
متن کاملEnergetics of Chloride Secretion
A bstract. Canine tracheal epithelium secretes Cl and absorbs Na; the energy for both is derived from the activity of the basolateral membrane Na-K-ATPase. These properties allowed us to examine the energetics of C1 secretion by directly comparing the metabolic cost of Cl transport with the metabolic cost ofNa transport. We measured the change in short-circuit current and 02 consumption rate th...
متن کاملCrofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels.
Crofelemer, a purified proanthocyanidin oligomer extracted from the bark latex of Croton lechleri, is in clinical trials for secretory diarrheas of various etiologies. We investigated the antisecretory mechanism of crofelemer by determining its effect on the major apical membrane transport and signaling processes involved in intestinal fluid transport. Using cell lines and measurement procedure...
متن کاملType IV neonatal Bartter syndrome complicated with congenital chloride diarrhea
BACKGROUND Pseudo-Bartter syndrome encompasses a heterogenous group of disorders similar to Bartter syndrome. Sometimes a few status may be nested, as in our case presented here. CASE REPORT An 8-month-old boy was referred to our hospital with of intractable diarrhea, polyuria, persistent hypokalemia, abdominal distension and failure to thrive. He was born in the 34 6/7 gestational week (GW) ...
متن کاملCongenital Chloride Diarrhea in Dizygotic Twins
Congenital chloride diarrhea (CLD) is a rare inherited autosomal recessive disorder. Mutations of the solute carrier family 26 member 3 gene cause profuse, chloride ion rich diarrhea, which results in hypochloremia, hyponatremia and metabolic alkalosis with dehydration. If a fetal ultrasound shows bowel dilatation suggestive of bowel obstruction, or if a neonate shows persistent diarrhea and me...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2017
ISSN: 0020-7136
DOI: 10.1002/ijc.31048