منابع مشابه
Proteoglycans and pathophysiology.
VENTILATION-INDUCED LUNG INJURY (VILI) is an important clinical entity whose pathophysiology is incompletely understood. The article by Moriondo and coworkers (14) in the Journal of Applied Physiology offers new insights into potential mechanistic pathways. These authors report that one of the earliest responses to mechanical ventilation in healthy rats is evidence of proteoglycan (PG) fragment...
متن کاملProteoglycans and brain repair.
Proteoglycans are complex molecules composed of long, unbranched sugar chains attached to a protein core. In the mammalian central nervous system, they are a major component of the extracellular matrix and of the cellular surface. After a central nervous system injury, their expression in the lesion area changes strongly and contributes to the inhibition of axon regrowth and brain repair.
متن کاملGlycosaminoglycans and Proteoglycans
In this editorial to MDPI Pharmaceuticals special issue "Glycosaminoglycans and Proteoglycans" we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan, serglycin, cell-surface proteoglycans, like syndecans and glypicans, and the extracellular matrix proteoglycans, like aggrecan, perlecan, and ...
متن کاملCartilage proteoglycans.
The predominant proteoglycan present in cartilage is the large chondroitin sulfate proteoglycan 'aggrecan'. Following its secretion, aggrecan self-assembles into a supramolecular structure with as many as 50 monomers bound to a filament of hyaluronan. Aggrecan serves a direct, primary role providing the osmotic resistance necessary for cartilage to resist compressive loads. Other proteoglycans ...
متن کاملTendon proteoglycans: biochemistry and function.
Tendon remodeling occurs in response to changes in loading and mobilization. Though the normal mechanical function depends on precise alignment of collagen fibrils, it is proteoglycans that regulate collagen fibrillogenesis and thus, indirectly, tendon function. In this paper we discuss the basic biochemical structure of several members of two proteoglycans families. Decorin, biglycan, fibromod...
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ژورنال
عنوان ژورنال: Experientia
سال: 1993
ISSN: 0014-4754,1420-9071
DOI: 10.1007/bf01923962