Coumarin (2H-1-Benzopyran-2-one) act against planktonic and biofilm forms of Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa

Introduction: biofilm-related infections caused by Staphylococcus aureus, Klebsi-ella pneumoniae and Pseudomonas aeruginosa are difficult to treat few effective pharmacological options currently available for this purpose. In context, coumarin (2H-1-Benzopyran-2-one) has been reported have antibacterial antibiofilm activity, but potential remains poorly understood. Aim: investi-gate the action of on planktonic biofilm forms S. K. pneu-moniae P. aeruginosa. Results: a minimum inhibitory concentration (MIC) ranging from 256 1024 μg/mL was observed, with remarkable ability inhibit formation biofilms act mature in concentrations close MIC. Conclusion: strong activity against three species great relevance clinical scenario. These results interesting enable alternative treatment these infections.