Cost of whole genome sequencing for non-typhoidal Salmonella enterica

Background While whole genome sequencing (WGS) may be more expensive than traditional testing and polymerase chain reaction (PCR), simple cost comparisons ignore the potential for WGS to reduce societal costs of non-typhoidal Salmonella enterica through public health action prevent illness. Methods We determined how many cases use data would need cost-equal serotyping MLVA, or culture independent based on PCR in Australia. then examined cost-savings current typing methods compared with outbreak scenarios. Results A median 275 (90% CrI -55-775) 1.9% -0.4%-5.4%) notified serotyped prevented 1,550 820–2,725) 9.6% all PCR. is likely result savings prolonged outbreaks, where can support earlier action. Conclusions Despite currently having a higher per isolate, routine was no existing >2% illness averted.