Corpus Callosotomy for Intractable Seizures

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Lamotrigine after corpus callosotomy

Corpus callosotomy (CC) has been employed in the management of intractable epilepsy since 1940’ and should be considered for patients with generalized falling seizures with physical injury, recurrent life-threatening generalized convulsive status epilepticus or atypical absence status’. CC is especially useful in improving seizure control in patients with tonic and atonic seizures3 and those wi...

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Reinventing the corpus callosotomy.

Surgical section of the corpus callosum is an old operation. It was first performed to treat epilepsy more than 75 years ago. Early procedures often consisted of a “total commissurotomy,” performed through a right frontoparietal craniotomy, with division of the entire corpus callosum, the ipsilateral fornix, the anterior commissure, and even the massa intermedia of the thalamus. Subsequently, s...

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Anterior corpus callosotomy in multistep invasive monitoring and surgery for atonic seizures☆☆☆

Identifying the epileptogenic zone (EZ) in patients with refractory nonlesional frontal lobe epilepsy is frequently challenging. Intracranial EEG (icEEG) recordings are often required to better delineate the EZ, but the presence of an extensive network of connections allowing rapid ictal spread may result in bilateral homologous regional (or extremely diffuse) electrical ictal patterns. Here, w...

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Corpus Callosotomy in Pediatric Intractable Epilepsy: Microsurgical Technique Implication and Variation

Medically intractable epilepsy is considered for surgical intervention first for resection of localized area of brain in which cases seizure control is expected generally. Nevertheless, those with non-localizing lesions in the imaging studies as well as multifocal spikes in electroencephalography (EEG) are not candidates for the resective surgery. For palliative intervention, corpus callosotomy...

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Evaluation of efficacy and safety of anterior corpus callosotomy with keyhole in refractory seizures

PURPOSE This study was conducted to evaluate the efficacy and safety of anterior corpus callosotomy with a keyhole approach on refractory seizures and to evaluate this procedure for drop attacks (DAs) and generalized tonic-clonic seizures (GTCSs). METHODS All refractory seizure patients underwent anterior corpus callosotomy (n=31) without other epilepsy surgery. Seizure response and procedure...

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ژورنال

عنوان ژورنال: Pediatric Neurology Briefs

سال: 1991

ISSN: 2166-6482,1043-3155

DOI: 10.15844/pedneurbriefs-5-4-5