Conservative therapy with metformin plus megestrol acetate for endometrial atypical hyperplasia
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منابع مشابه
Conservative therapy with metformin plus megestrol acetate for endometrial atypical hyperplasia
OBJECTIVE To compare the efficacy of metformin plus megestrol acetate (MA) with that of MA alone for treating endometrial atypical hyperplasia (EAH). METHODS This pilot study included 16 EAH patients who met at least one metabolic syndrome (MS) criterion and received either adjunctive metformin plus MA (MET group) or MA monotherapy (MA group). Each patient in the MA group received 160 mg of M...
متن کاملPhase II study of medroxyprogesterone acetate plus metformin as a fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer.
BACKGROUND Metformin, widely used in the treatment of type 2 diabetes mellitus, reduces the risk of cancer and relapse after treatment. Fertility-sparing treatment for endometrial cancer (EC) with progestin is associated with a high chance of disease regression, and the high relapse rate continues to be a problem. We assessed the efficacy of metformin in preventing recurrence after medroxyproge...
متن کاملMetformin for endometrial hyperplasia: a Cochrane protocol
INTRODUCTION Endometrial hyperplasia is a precancerous lesion of the endometrium, commonly presenting with uterine bleeding. If managed expectantly, it frequently progresses to endometrial carcinoma, rates of which are increasing dramatically worldwide. However, the established treatment for endometrial hyperplasia (progestogens) involves multiple side effects and leaves the risk of recurrence....
متن کاملEvaluation of the Effect of Additive Metformin to Progesterone on Patients with Endometrial Hyperplasia
Background and Objectives: Endometrial hyperplasia (EH) is an abnormal overgrowth of endometrium that may lead to endometrial cancer, especially when accompanied by atypia. The treatment of EH is challenging, and previous studies report conflicting results. Metformin (dimethyl biguanide) is an anti-diabetic and insulin sensitizer agent, which is supposed to have antiproliferative and anticancer...
متن کاملConservative treatment for atypical endometrial hyperplasia: what is the most effective therapeutic method?
especially in the presence of atypia, has a strong tendency to the development of endo-metrial carcinoma. In this respect, hysterectomy is a preferred treatment for atypical EH. However, for young patient who desire to preserve their fertility or for patients not selected for surgery, conservative treatments using progestin are widely accepted as a treatment option [1]. Oral use of progestin, s...
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ژورنال
عنوان ژورنال: Journal of Gynecologic Oncology
سال: 2014
ISSN: 2005-0380,2005-0399
DOI: 10.3802/jgo.2014.25.3.214