Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy
نویسندگان
چکیده
منابع مشابه
Computational design of self-assembling protein nanomaterials with atomic level accuracy.
We describe a general computational method for designing proteins that self-assemble to a desired symmetric architecture. Protein building blocks are docked together symmetrically to identify complementary packing arrangements, and low-energy protein-protein interfaces are then designed between the building blocks in order to drive self-assembly. We used trimeric protein building blocks to desi...
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ژورنال
عنوان ژورنال: Science
سال: 2012
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1219364