Composition and chronic toxicity of dry methanol-aqueous extract of wild-growing Satureja montana

Introduction : Satureja montana is a wild growing medicinal plant, part of the Lamiaceae family. This herb well known as source phenolic compounds, which can vary in broad range depending on different factors and exert many pharmacological activities. Aim The aim study was to investigate composition chronic toxicity dry extract . Material methods investigated by high-performance liquid chromatographic system with diode-array detector. To establish we used 40 eight-week-old male Wistar rats, treated orally saline, olive oil (control groups), at dose 500 mg/kg bw, carvacrol – rosmarinic acid 15 bw. animals were sacrificed end experiment blood samples organs for histological examination obtained. Statistical analysis performed one-way variance (ANOVA) using IBM SPSS 19.0. Results Rosmarinic small quantities found Full count biochemical parameters ASAT, ALAT, uric acid, cholesterol, triglycerides, glucose ionized Ca reference values 17+ weeks old rats. showed no signs organ toxicity. Conclusions main ingredient acid. not toxic after 90-days oral administration.