Complexing of bacterial lipopolysaccharide with lung surfactant
نویسندگان
چکیده
منابع مشابه
Identifying Macromolecules The authors review a surface enhanced laser Raman spectroscopy study of lung surfactant protein interaction with bacterial lipopolysaccharide
The molecular architecture of the surfactant lipoprotein system is important in understanding its interaction with the microbial world. It consists of 90% lipids — mainly phospholipids — and 5–10% specific lipoproteins consisting of four major apoproteins (SP-A, SP-B, SP-C, and SP-D). The importance of SP-A and SP-D for innate immunity of the lung is recognized now (1,2). The surfactant complex...
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Infection of the respiratory tract is a frequent cause of lung pathologies, morbidity, and death. When bacterial endotoxin [lipopolysaccharide (LPS)] reaches the alveolar spaces, it encounters the lipid-rich surfactant that covers the epithelium. Although binding of hydrophilic surfactant protein (SP) A and SP-D with LPS has been established, nothing has been reported to date on possible cross ...
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The study was designed to prove the hypothesis that lipopolysaccharide (LPS)-induced fever elicits the changes in surfactant specific proteins, potentially related to thermal tachypnea. In adult rats fever was induced by intraperitoneal administration of LPS at a dose 100 microg/kg of body weight; control group received saline. Respiratory parameters, arterial blood gases and pH and colonic bod...
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In addition to their effects on alveolar surface tension, some components of lung surfactant also have immunological functions. We found recently that the hydrophobic lung surfactant protein SP-C specifically binds to the lipid A region of lipopolysaccharide (LPS). In this study, we show that SP-C also interacts with CD14. Four observations showed cross talk between the three molecules SP-C, LP...
متن کاملLung surfactant.
Aspects of pulmonary surfactant are reviewed from a biochemical perspective. The major emphasis is on the lipid components of surfactant. Topics reviewed include surfactant composition, cellular and subcellular sites as well as pathways of biosynthesis of phosphatidylcholine, disaturated phosphatidylcholine and phosphatidylglycerol. The surfactant system in the developing fetus and neonate is c...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1986
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.52.3.644-649.1986