Competitive Inhibition of Pepsin by Carboxylic Acids
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چکیده
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Understanding biocatalyst inhibition by carboxylic acids
Carboxylic acids are an attractive biorenewable chemical in terms of their flexibility and usage as precursors for a variety of industrial chemicals. It has been demonstrated that such carboxylic acids can be fermentatively produced using engineered microbes, such as Escherichia coli and Saccharomyces cerevisiae. However, like many other attractive biorenewable fuels and chemicals, carboxylic a...
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substrates with fructose 6-phosphate as the first substrate to combine and fructose 1.6-bisphosphate as the last product to leave the enzyme. The observed product-inhibition patterns would be consistent with a random mechanism if the three dead-end complexes (fructose 1,6-bisphosphate~nzyme-ATP, ADP-enzymcfructose 6-phosphate and ADP-enzymcATP) were able to form. However, initial-rate studies o...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1970
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.43.3472