Comparison of Vitamin K Activities of Vitamin K1 and Klotogen (Menadione Sodium Bisulfite Complex)

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Dietary vitamin K1 requirement and comparison of biopotency of different vitamin K sources for young turkeys.

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Menadione is a metabolite of oral vitamin K.

Phylloquinone is converted into menaquinone-4 and accumulates in extrahepatic tissues. Neither the route nor the function of the conversion is known. One possible metabolic route might be the release of menadione from phylloquinone by catabolic activity. In the present study we explored the presence of menadione in urine and the effect of vitamin K intake on its excretion. Menadione in urine wa...

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Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats.

Mice have the ability to convert dietary phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) and store the latter in tissues. A prenyltransferase enzyme, UbiA prenyltransferase domain-containing 1 (UBIAD1), is involved in this conversion. There is evidence that UBIAD1 has a weak side chain cleavage activity for phylloquinone but a strong prenylation activity for menadione (vitamin K3), w...

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ژورنال

عنوان ژورنال: Poultry Science

سال: 1957

ISSN: 0032-5791

DOI: 10.3382/ps.0360633