Columbus runs aground Christmas Eve, 1492

Dmd058008 1485..1492

Tegafur (FT), a prodrug of 5-fluorouracil, is a chiral molecule, a racemate of Rand S-isomers, and CYP2A6 plays an important role in the enantioselective metabolism of FT in human liver microsomes (R-FT >> S-FT). This study examined the enantioselective metabolism of FT by microsomes prepared from Sf9 cells expressing wildtype CYP2A6 and its variants (CYP2A6*7, *8, *10, and *11) that are highly...

ISS: Columbus.

In 2001, a total of 13 assembly and logistic flights to the ISS were made, using both Russian launchers and the Space Shuttle, including flights of the first European astronauts, payloads and Multi-Purpose Logistics Modules (MPLMs). Several US, Russian and Canadian elements have already been assembled in orbit and the fourth Expedition Crew is currently onboard. The cornerstone of ESA's contrib...

The Digital Behaim Globe (1492)

The goal of most hypermedia systems is to open up complex information spaces through the use of associative networks of nodes containing texts, images, and acoustic signals. The power of such information systems can be considerably enhanced by the integration of knowledge representation. We illustrate this claimwith an example hypermedia information system about the oldest existing globe of the...

Christmas Days

Some of the achievements at festivities and exhibitions are greeted with surprise. It is not always possible to have the privilege of personal inspection, though those in charge of defectives are usually most ready to give of their precious leisure in showingvisitors what is being done.. The following notes giving different accounts of Christmas activities have been kindly sent to us. They may ...

Christmas disease.