Clotting profiles and coagulation factors

Different recovery profiles of coagulation factors, thrombin generation, and coagulation function after hemorrhagic shock in pigs.

BACKGROUND Hemorrhagic shock contributes to coagulopathy after trauma. We investigated daily changes of coagulation components and coagulation function for 5 days in hemorrhaged and resuscitated pigs. METHODS Fourteen pigs were randomized into the sham control (C) and the hemorrhage and lactated Ringer's resuscitation (H-LR) groups. On day 1, hemorrhage was induced in the H-LR group by bleedi...

Theories of blood coagulation. Properties and interactions of blood clotting factors.

Two main schools of thought dominate the scene of blood coagulation and hemo­ stasis today. Both have their roots in the classic theory of blood coagulation (figure 1) described by Paul Morawitz in 1904.20 In the primitive physiological and bio­ chemical background of that period the formation of a blood clot was envisioned correctly as the result of the conversion of prothrombin to thrombin by...

Recombinant clotting factors.

The recombinant era for haemophilia began in the early 1980s with the cloning and subsequent expression of functional proteins for both factors VIII and IX. Efficient production of recombinant clotting factors in mammalian cell culture systems required overcoming significant challenges due to the complex post-translational modifications that were integral to their pro-coagulant function. The qu...

Waveform analysis of clotting test optical profiles in the diagnosis and management of disseminated intravascular coagulation (DIC).

Transmittance waveform charts the changes in light transmittance on standard coagulation assays, such as the prothrombin time (PT) and activated partial thromboplastin time (APTT). Analysis and characterization of these data on photo-optical coagulation analysers provides additional qualitative and quantitative information to that obtained using the clotting time alone. The most thoroughly eval...

Nomenclature for blood clotting factors.