CLL kinetics in the tumor microenvironment

CLL kinetics in the tumor microenvironment

Cumulative evidence points to the importance of the tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) pathogenesis [1]. In vitro, co-culture systems that mimic microenvironmental stimuli are necessary to sustain tumor cells. In vivo, engraftment of CLL cells in immunocompromised mice depends on the presence of autologous CD4+ T cells. In patients, the effects of the TME on tumo...

Tumor suppressors revival in CLL

A Mimic of the Tumor Microenvironment on GPR30 Gene Expression in Breast Cancer

Introduction: The G-protein coupled receptor 30 (GPR30) gene is a member of the G-protein coupled receptor (GPCR) family; involved in breast, endometrial, and ovarian cancers. Many GPCR receptors that are implicated in several types of human cancers are correlated with increased cell proliferation and tumor progression; especially GPR30 gene. Methods: The breast cancer MCF-7 and MDA-MB-231 cel...

Tumor Microenvironment in the Brain

In addition to malignant cancer cells, tumors contain a variety of different stromal cells that constitute the tumor microenvironment. Some of these cell types provide crucial support for tumor growth, while others have been suggested to actually inhibit tumor progression. The composition of tumor microenvironment varies depending on the tumor site. The brain in particular consists of numerous ...

The brain tumor microenvironment.

High-grade brain tumors are heterogeneous with respect to the composition of bona fide tumor cells and with respect to a range of intermingling parenchymal cells. Glioblastomas harbor multiple cell types, some with increased tumorigenicity and stem cell-like capacity. The stem-like cells maybe the cells of origin for tumor relapse. However, the tumor-associated parenchymal cells such as vascula...