Clinical pharmacological studies with doxazosin.

Clinical and Pharmacological Studies of Orofacial Pain

s Vickers ER and Punnia-Moorthy A (1993). Chronic dentofacial pain: demographic, social and pain characteristics in 100 patients. XIVth Australian Pain Society Conference, Melbourne, February:45. Vickers ER and Marzbani N (1994). Dentistry without injections: the efficacy of topical anaesthesia. XVth Australian Pain Society Conference, Brisbane, April:119. Vickers ER and Cousins MJ (1995). Diag...

Pharmacological studies with 5-fluorocytosine.

A cylinder plate bioassay for 5-fluorocytosine (5-FC) is described which permits determination of 5-FC concentrations in biological fluids in the presence of amphotericin B. Using this assay, we determined serum concentrations in 12 patients after a single dose of drug and in 8 patients receiving daily 5-FC at 6-hr intervals (4 to 120 days). Drug was detectable in serum as early as 0.5 hr and c...

Clinical pharmacological studies of amoxycillin: effect of probenecid.

In a study of eight, healthy adult volunteers given 3 g amoxycillin with or without 1g probenecid, significantly higher peak plasma levels of amoxycilin were recorded in the presence (34.96 microgram/ml) of probenecid than in its absence (22.72 microgram/ml). When plasma levels were plotted against time the mean area under the curve was significantly greater for subjects given probenecid than f...

Clinical pharmacological studies of Kö 1173--a new antiarrhythmic agent.

Clinical and pharmacological studies of ticarcillin in gram-negative infections.

Twenty-seven patients with serious gram-negative infections were treated with ticarcillin in an average daily dosage of 237 mg/kg (range, 174 to 307 mg/kg). Ticarcillin was bactericidal for all infecting organisms in concentrations ranging from 31.2 to 125 mug/ml. Five of 8 patients (62%) with overwhelming Pseudomonas pneumonia were cured or improved, and 9 of 12 (75%) were cured of pneumonia c...