Cisplatin-induced Nephrotoxicty and its Predisposing Factors for Unrecovered Kidney Injury: A Report from Indonesia National Cancer Center

BACKGROUND: Cisplatin-induced nephrotoxicity is the most common and devastating side effects which affects long-term outcome. It may be reversible in some patients but also cause permanent kidney injury. AIM: This research aims to evaluate risk factors of cisplatin unrecovered function at national cancer hospital Indonesia. METHODS: a retrospective cohort study conducted Dharmais National Cancer Hospital, Jakarta, All aged 18 years old above, who received cisplatin-based regimen as first-line chemotherapy completing all cycles with least four cycles, were included study. Demographic data collected was evaluated using estimated glomerular filtration rate (eGFR) before, 3 times during chemotherapy, 1 months after last dose. RESULTS: A total 177 analysis, mean age 45.80 ± 11.75 old, majority diagnosed nasopharynx (58.8%), have baseline eGFR 102.76 20.68 mL/min 1.73m2. Nephrotoxicity occurred 80 (45.2%) 27 (15.3%) toxicity first cycle. Age above 50, hypertension non-steroidal anti-inflammatory drugs (NSAID) use associated increased cisplatin-induced nephrotoxicity. include 50 (OR 4.18, 95% CI 2.11–8.28; p < 0.0001), 2.03, 1.03–4.01; = 0.040), NSAID 2.34, 1.22–4.93; 0.025). Risk 75% 0.47, 0.17–0.56; 0.001) gender 0.018, 0.03–0.95; 0.043). CONCLUSION: occurs 45.2% throughout cycles. includes hypertension, while female are factor for not recover