Chronic Trigemino-Cardiac Reflex: An Underestimated Truth

Chronic Trigemino-Cardiac Reflex: An Underestimated Truth

The trigemino-cardiac reflex (TCR) is a brainstem reflex that manifests as adverse cardiorespiratory events upon the stimulation of sensory branches of the fifth cranial nerve. This reflex is mainly investigated in different neurosurgical procedures and intervention. This reflex is commonly considered as an acute and mild physiological response. On the other hand, more devastating and chronic n...

Topical lidocaine to suppress trigemino-cardiac reflex.

Sleep Disorders: Is the Trigemino-Cardiac Reflex a Missing Link?

Trigeminal innervated areas in face, nasolacrimal, and nasal mucosa can produce a wide array of cardiorespiratory manifestations that include apnea, bradypnea, bradycardia, hypotension, and arrhythmias. This reflex is a well-known entity called "trigemino-cardiac reflex" (TCR). The role of TCR is investigated in various pathophysiological conditions especially in neurosurgical, but also skull b...

Trigemino-cardiac reflex during chronic subdural haematoma removal: report of chemical initiation of dural sensitization

The trigemino-cardiac reflex is a well-known clinical phenomenon described during different craniofacial or skull base surgery as well as neuroradiological interventions and defined as the sudden onset of parasympathetic dysrhythmia, sympathetic hypotension, apnea, or gastric hyper-motility during (intraoperative) stimulation of any of the sensory branches of the trigeminal nerve. According to ...

The trigemino-cardiac reflex: a view to the future

After the trigemino-cardiac reflex (TCR) was first described by the senior author in 1999 [1], it resolved one of the great problems and mysteries in neurosurgery. In the meantime, several other groups have published their results about the TCR, but there still remain a lot of questions about this reflex that are currently unresolved. Our group has recently published an important update of the ...