Chronic phenytoin therapy-induced vecuronium resistance
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics and pharmacodynamics of vecuronium in children receiving phenytoin or carbamazepine for chronic anticonvulsant therapy.
The pharmacokinetics and time course of action of vecuronium in normal children and children receiving anticonvulsant drugs for prolonged periods were characterized. A bolus dose of vecuronium 0.15 mg kg(-1) was administered i.v. to 10 non-epileptic children and to 10 children on phenytoin and 10 children on carbamazepine, who were matched for age and weight. Plasma concentrations of vecuronium...
متن کاملInfluence of chronic phenytoin administration on the pharmacokinetics and pharmacodynamics of vecuronium.
BACKGROUND The duration of action of vecuronium is reduced in patients receiving phenytoin. In this study, the authors examined, simultaneously, the influence of phenytoin on both the pharmacokinetics and the pharmacodynamics of vecuronium. METHODS This study was approved by the institutional review board of the University of California, San Francisco, and patients gave written informed conse...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmacology
سال: 2011
ISSN: 0253-7613
DOI: 10.4103/0253-7613.77378