Chondrogenesis, bone morphogenetic protein-4 and mesenchymal stem cells
نویسندگان
چکیده
منابع مشابه
Transcriptome analysis of early chondrogenesis in ATDC5 cells induced by bone morphogenetic protein 4.
We performed serial analysis of gene expression (SAGE) profiling in mouse chondrogenic ATDC5 cells before and 6 h after the onset of chondrogenesis induced by BMP4. A total of 43,656 SAGE tags (21,875 and 21,781 tags from the uninduced and induced libraries, respectively) were analyzed. Our analysis predicted that 139 transcripts were differentially represented in the two libraries (p < 0.05), ...
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INTRODUCTION The present study compares bone morphogenetic protein (BMP)-4 and BMP-2 gene transfer as agents of chondrogenesis and hypertrophy in human primary mesenchymal stem cells (MSCs) maintained as pellet cultures. METHODS Adenoviral vectors carrying cDNA encoding human BMP-4 (Ad.BMP-4) were constructed by cre-lox combination and compared to previously generated adenoviral vectors for B...
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objective: in this study, we examined the effect of different doses of bone morphogenetic protein 4 (bmp4) on cce mouse embryonic stem cells (escs) viability and proliferation rates in order to improve the outcome of induction processes and make a system with highest viability and proliferation rates for further studies on bmp4 roles in multiple developmental stages. materials and methods: expr...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2008
ISSN: 1063-4584
DOI: 10.1016/j.joca.2008.03.003