CHOLINE ANTIMETABOLITES. STUDIES IN MICROORGANISMS
نویسندگان
چکیده
منابع مشابه
Choline anitmetabolites. Studies in microorganisms.
We have described previously (1) the study in vitro of a series of analogues and homologues of choline as substrates for the enzyme choline dehydrogenase. These compounds consisted of methylated and ethylated products, both simple and mixed, of ethanolamine, 1-aminopropanol-3, 2-amino-2-methylpropanol-1, 1-aminopropanol-2, and 2-amino-2-methyl1,3-propanediol, together with the parent amines. Of...
متن کاملStudies of Antimetabolites* Ii. I-acetylpyridine
When 3acetylpyridine (3-AP) is fed to dogs, large amounts of a normal end-product of nicotinic acid metabolism, N’-methylnicotinamide (NMeN), appear in the urine (1). This finding might be interpreted as evidence that 3-AP, acting as an antivitamin, displaces nicotinamide from its nucleotides or prevents its incorporation therein, or, alternatively, that 3-AP is biologically oxidized to nicotin...
متن کاملStudies of antimetabolites. II. 3-Acetylpyridine.
When 3acetylpyridine (3-AP) is fed to dogs, large amounts of a normal end-product of nicotinic acid metabolism, N’-methylnicotinamide (NMeN), appear in the urine (1). This finding might be interpreted as evidence that 3-AP, acting as an antivitamin, displaces nicotinamide from its nucleotides or prevents its incorporation therein, or, alternatively, that 3-AP is biologically oxidized to nicotin...
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Pettus gave everything he had as a medical missionary in China and Dr. Edward H. Hume has drawn a clear and sympathetic picture of this man, his aspirations, and those qualities which distinguished him as a medical scientist at home and abroad. On 23 November 1945 was received the melancholy cablegram from Huangping, China, which read as follows: "Dr. Pettus killed in airplane accident at Huang...
متن کاملStudies on the Specificity of Choline Esterase
The present investigation was undertaken to determine the relation between the structure of various substrates and the action of serum choline esterase upon them. The comparison of activities with different esters should take into account two factors : the hydrolytic velocities compared should be linear functions of time, and these velocities should be independent of substrate concentration. Th...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1956
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(20)89948-7