Characterization of the Laminin Binding Domains of the Lutheran Blood Group Glycoprotein
نویسندگان
چکیده
منابع مشابه
The Laminin 511 / 521 – binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3 Tosti
1Bristol Institute for Transfusion Sciences (BITS), National Blood Service, Bristol, United Kingdom; 2Department of Biochemistry, University of Bristol, Bristol, United Kingdom; 3Department of Chemistry, University of Aarhus, Aarhus, Denmark; 4School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom; 5New York Blood Center, New York City; and 6University of Californi...
متن کاملThe Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3.
The Lutheran blood group glycoprotein, first discovered on erythrocytes, is widely expressed in human tissues. It is a ligand for the alpha5 subunit of Laminin 511/521, an extracellular matrix protein. This interaction may contribute to vaso-occlusive events that are an important cause of morbidity in sickle cell disease. Using x-ray crystallography, small-angle x-ray scattering, and site-direc...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m102978200