Cerebral Blood Flow Response to Functional Activation

Cerebral blood flow response to hypoglycemia in type 1 diabetes

Introduction Patients with type 1 diabetes and hypoglycemia unawareness have a reduction in the hormonal counterregulatory response to decreasing blood glucose (BG) levels and are unable to detect hypoglycemia before they become neuroglycopenic. A critical brain region for BG sensing is the hypothalamus. PET studies (Teves et al., 2004) as well as MRI studies (Page et al., 2009) have shown incr...

Cerebral blood flow response to acute hypoxic hypoxia

Hypoxic hypoxia (inspiratory hypoxia) stimulates an increase in cerebral blood flow (CBF) maintaining oxygen delivery to the brain. However, this response, particularly at the tissue level, is not well characterised. This study quantifies the CBF response to acute hypoxic hypoxia in healthy subjects. A 20-min hypoxic (mean P(ETO2) = 52 mmHg) challenge was induced and controlled by dynamic end-t...

Response to "do vasomotor nerves significantly regulate cerebral blood flow?".

Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation.

A simple instrument is demonstrated for high-resolution simultaneous imaging of total hemoglobin concentration and oxygenation and blood flow in the brain by combining rapid multiwavelength imaging with laser speckle contrast imaging. The instrument was used to image changes in oxyhemoglobin and deoxyhemoglobin and blood flow during cortical spreading depression and single whisker stimulation i...

Functional activation of cerebral blood flow and metabolism before and after global ischemia of rat brain.

The effect of somatosensory stimulation on the local CBF (LCBF), CMRglu (LCMRglu), tissue pH, and tissue content of ATP, glucose, and lactate was studied in chloralose-anesthetized rats before and after 30 min of near-complete forebrain ischemia. In nonischemic rats LCBF in primary somatosensory cortex increased by 33%, LCMRglu increased by 55%, tissue glucose content decreased by 21%, and lact...