Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload

Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload.

AIMS To develop and validate a non-invasive method for measuring myocardial iron in order to allow diagnosis and treatment before overt cardiomyopathy and failure develops. METHODS AND RESULTS We have developed a new magnetic resonance T2-star (T2*) technique for the measurement of tissue iron, with validation to chemical estimation of iron in patients undergoing liver biopsy. To assess the c...

T2-star (T2*) magnetic resonance imaging for assessment of kidney iron overload in thalassemic patients.

BACKGROUND Improved survival in thalassemic patients has lead to the manifestation of morbidities such as renal dysfunction. This involvement suggests the need for a reliable and non-invasive method to assess the degree of kidney iron overload. We conducted the present study to evaluate the relationship between serum ferritin levels, liver, heart, and kidney MRI gradient echo (T2*) relaxation t...

Evaluation of myocardial iron overload by T2* cardiovascular magnetic resonance imaging.

On T2* magnetic resonance and cardiac iron.

BACKGROUND Measurement of myocardial iron is key to the clinical management of patients at risk of siderotic cardiomyopathy. The cardiovascular magnetic resonance relaxation parameter R2* (assessed clinically via its reciprocal, T2*) measured in the ventricular septum is used to assess cardiac iron, but iron calibration and distribution data in humans are limited. METHODS AND RESULTS Twelve h...

T2* magnetic resonance: iron and gold.

As a clinician, it is important to never underestimate the power of basic science to deliver new answers to old questions. At the outset of the development of magnetic resonance (MR), scientists demonstrated differences in magnetic relaxation between normal and malignant tissues that were of significant interest, although only clinically exploited later through MR spectroscopy. Some 30 years on...