منابع مشابه
Transformation of rat embryo cells in vitro by chemical carcinogens.
The in vitro transformation of mouse and hamster cells by chemical carcinogens has been described and well established. (1—5, 8, 13, 19, 20). Most in vitro transformations of cell cultures by chemical carcinogens yielded sarcomas upon reinsertion into syngeneic hosts. Transformation of rat embryo cells by 4-nitroquinoline 1-oxide (15) and fluorenylhydroxamic acids (7) has been reported recent...
متن کاملCharacteristic expression profiles induced by genotoxic carcinogens in rat liver.
When applied in toxicological studies, the recently developed gene expression profiling techniques using microarrays, which brought forth the new field of toxicogenomics, facilitate the interpretation of a toxic compound's mechanism of action. In this study, we investigated whether genotoxic carcinogens at doses known to induce liver tumors in the 2-year rat bioassay deregulate a common set of ...
متن کاملActivation of carcinogens and mutagens by rat colon mucosa.
Colon mucosal cells can catalyze the activation of precarcinogens to mutagenic metabolites without the intermediacy of intestinal bacteria as shown in a mutagenesis assay system composed of Salmonella typhimurium strain TA100 and the 9000 X g supernatant fraction of rat colon mucosal cells. Pretreatment of rats with beta-naphtoflavone increased the activation of 2-aminoanthracene 10- to 20-fold...
متن کاملBinding of chemical carcinogens to nuclear proteins of rat liver.
liver nuclei was studied. After the injection of the radioactive carcinogens into rats, liver histone fractions Fl, F2al, F2a2, F2b, and F3 were isolated by selective acid extraction. DNA and acidic proteins were extracted with 4 M CsCl at pH 11.6 and 14 and were separated by equilibrium density centrifugation. Histones and acidic proteins were purified by Sephadex chiomatography. Maximum level...
متن کاملBinding of Chemical Carcinogens to Nuclear Proteins of Rat Liver1
liver nuclei was studied. After the injection of the radioactive carcinogens into rats, liver histone fractions Fl, F2al, F2a2, F2b, and F3 were isolated by selective acid extraction. DNA and acidic proteins were extracted with 4 M CsCl at pH 11.6 and 14 and were separated by equilibrium density centrifugation. Histones and acidic proteins were purified by Sephadex chiomatography. Maximum level...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1974
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1974.187